Anti-Doping Convention, (ETS No. 135), entered into force January 3, 1990.

 

Reference List

Preamble

    The member States of the Council of Europe, the other States party to the European Cultural Convention, and other States, signatory hereto,

    Considering that the aim of the Council of Europe is to achieve a greater unity between its members for the purpose of safeguarding and realising the ideals and principles which are their common heritage and facilitating their economic and social progress;

    Conscious that sport should play an important role in the protection of health, in moral and physical education and in promoting international understanding;

    Concerned by the growing use of doping agents and methods by sportsmen and sportswomen throughout sport and the consequences thereof for the health of participants and the future of sport;

    Mindful that this problem puts at risk the ethical principles and educational values embodied in the Olympic Charter, in the International Charter for Sport and Physical Education of Unesco and in Resolution (76) 41 of the Committee of Ministers of the Council of Europe, known as the "European Sport for All Charter";

    Bearing in mind the anti-doping regulations, policies and declarations adopted by the international sports organisations;

    Aware that public authorities and the voluntary sports organisations have complementary responsibilities to combat doping in sport, notably to ensure the proper conduct, on the basis of the principle of fair play, of sports events and to protect the health of those that take part in them;

    Recognising that these authorities and organisations must work together for these purposes at all appropriate levels;

    Recalling the resolutions on doping adopted by the Conference of European Ministers responsible for Sport, and in particular Resolution No. 1 adopted at the 6th Conference at Reykjavik in 1989;

    Recalling that the Committee of Ministers of the Council of Europe has already adopted Resolution (67) 12 on the doping of athletes, Recommendation No. R (79) 8 on doping in sport, Recommendation No. R (84) 19 on the "European Anti-doping Charter for Sport", and Recommendation No. R (88) 12 on the institution of doping controls without warning outside competitions;

    Recalling Recommendation No. 5 on doping adopted by the 2nd International Conference of Ministers and Senior Officials responsible for Sport and Physical Education organised by Unesco at Moscow (1988);

    Determined however to take further and stronger co-operative action aimed at the reduction and eventual elimination of doping in sport using as a basis the ethical values and practical measures contained in those instruments,

    Have agreed as follows:

    The Parties, with a view to the reduction and eventual elimination of doping in sport, undertake, within the limits of their respective constitutional provisions, to take the steps necessary to apply the provisions of this Convention.

  1. For the purposes of this Convention:
    1. "doping in sport" means the administration to sportsmen or sportswomen, or the use by them, of pharmacological classes of doping agents or doping methods;
    2. "pharmacological classes of doping agents or doping methods" means, subject to paragraph 2 below, those classes of doping agents or doping methods banned by the relevant international sports organisations and appearing in lists that have been approved by the monitoring group under the terms of Article 11.1.b;
    3. "sportsmen and sportswomen" means those persons who participate regularly in organised sports activities.
  2. Until such time as a list of banned pharmacological classes of doping agents and doping methods is approved by the monitoring group under the terms of Article 11.1.b, the reference list in the appendix to this Convention shall apply.
  1. The Parties shall co-ordinate the policies and actions of their government departments and other public agencies concerned with combating doping in sport.
  2. They shall ensure that there is practical application of this Convention, and in particular that the requirements under Article 7 are met, by entrusting, where appropriate, the implementation of some of the provisions of this Convention to a designated governmental or non-governmental sports authority or to a sports organisation.
  1. The Parties shall adopt where appropriate legislation, regulations or administrative measures to restrict the availability (including provisions to control movement, possession, importation, distribution and sale) as well as the use in sport of banned doping agents and doping methods and in particular anabolic steroids.
  2. To this end, the Parties or, where appropriate, the relevant non-governmental organisations shall make it a criterion for the grant of public subsidies to sports organisations that they effectively apply anti-doping regulations.
  3. Furthermore, the Parties shall:
    1. assist their sports organisations to finance doping controls and analyses, either by direct subsidies or grants, or by recognising the costs of such controls and analyses when determining the overall subsidies or grants to be awarded to those organisations;
    2. take appropriate steps to withhold the grant of subsidies from public funds, for training purposes, to individual sportsmen and sportswomen who have been suspended following a doping offence in sport, during the period of their suspension;
    3. encourage and, where appropriate, facilitate the carrying out by their sports organisations of the doping controls required by the competent international sports organisations whether during or outside competitions; and
    4. encourage and facilitate the negotiation by sports organisations of agreements permitting their members to be tested by duly authorised doping control teams in other countries.
  4. Parties reserve the right to adopt anti-doping regulations and to organise doping controls on their own initiative and on their own responsibility, provided that they are compatible with the relevant principles of this Convention.
  1. Each Party undertakes:
    1. either to establish or facilitate the establishment on its territory of one or more doping control laboratories suitable for consideration for accreditation under the criteria adopted by the relevant international sports organisations and approved by the monitoring group under the terms of Article 11.1.b; or
    2. to assist its sports organisations to gain access to such a laboratory on the territory of another Party.
  2. These laboratories shall be encouraged to:
    1. take appropriate action to employ and retain, train and retrain qualified staff;
    2. undertake appropriate programmes of research and development into doping agents and methods used, or thought to be used, for the purposes of doping in sport and into analytical biochemistry and pharmacology with a view to obtaining a better understanding of the effects of various substances upon the human body and their consequences for athletic performance;
    3. publish and circulate promptly new data from their research.
  1. The Parties undertake to devise and implement, where appropriate in co-operation with the sports organisations concerned and the mass media, educational programmes and information campaigns emphasising the dangers to health inherent in doping and its harm to the ethical values of sport. Such programmes and campaigns shall be directed at both young people in schools and sports clubs and their parents and at adult sportsmen and sportswomen, sports officials, coaches and trainers. For those involved in medicine, such educational programmes will emphasise respect for medical ethics.
  2. The Parties undertake to encourage and promote research, in co-operation with the regional, national and international sports organisations concerned, into ways and means of devising scientifically-based physiological and psychological training programmes that respect the integrity of the human person.
  1. The Parties undertake to encourage their sports organisations and through them the international sports organisations to formulate and apply all appropriate measures, falling within their competence, against doping in sport.
  2. To this end, they shall encourage their sports organisations to clarify and harmonise their respective rights, obligations and duties, in particular by harmonising their:
    1. anti-doping regulations on the basis of the regulations agreed by the relevant international sports organisations;
    2. lists of banned pharmacological classes of doping agents and banned doping methods on the basis of the lists agreed by the relevant international sports organisations;
    3. doping control procedures;
    4. disciplinary procedures, applying agreed international principles of natural justice and ensuring respect for the fundamental rights of suspected sportsmen and sportswomen; these principles will include:
      1. the reporting and disciplinary bodies to be distinct from one another;
      2. the right of such persons to a fair hearing and to be assisted or represented;
      3. clear and enforceable provisions for appealing against any judgment made;
    5. procedures for the imposition of effective penalties for officials, doctors, veterinary doctors, coaches, physiotherapists and other officials or accessories associated with infringements of the anti-doping regulations by sportsmen and sportswomen;
    6. procedures for the mutual recognition of suspensions and other penalties imposed by other sports organisations in the same or other countries.
  3. Moreover, the Parties shall encourage their sports organisations:
    1. to introduce, on an effective scale, doping controls not only at, but also without advance warning at any appropriate time outside, competitions, such controls to be conducted in a way which is equitable for all sportsmen and sportswomen and which include testing and retesting of persons selected, where appropriate, on a random basis;
    2. to negotiate agreements with sports organisations of other countries permitting a sportsman or sportswoman training in another country to be tested by a duly authorised doping control team of that country;
    3. to clarify and harmonise regulations on eligibility to take part in sports events which will include anti-doping criteria;
    4. to promote active participation by sportsmen and sportswomen themselves in the anti-doping work of international sports organisations;
    5. to make full and efficient use of the facilities available for doping analysis at the laboratories provided for by Article 5, both during and outside sports competitions;
    6. to study scientific training methods and to devise guidelines to protect sportsmen and sportswomen of all ages appropriate for each sport.
  1. The Parties shall co-operate closely on the matters covered by this Convention and shall encourage similar co-operation amongst their sports organisations.
  2. The Parties undertake:
    1. to encourage their sports organisations to operate in a manner that promotes application of the provisions of this Convention within all the appropriate international sports organisations to which they are affiliated, including the refusal to ratify claims for world or regional records unless accompanied by an authenticated negative doping control report;
    2. to promote co-operation between the staffs of their doping control laboratories established or operating in pursuance of Article 5; and
    3. to initiate bilateral and multilateral co-operation between their appropriate agencies, authorities and organisations in order to achieve, at the international level as well, the purposes set out in Article 4.1.
  3. The Parties with laboratories established or operating in pursuance of Article 5 undertake to assist other Parties to enable them to acquire the experience, skills and techniques necessary to establish their own laboratories.

    Each Party shall forward to the Secretary General of the Council of Europe, in one of the official languages of the Council of Europe, all relevant information concerning legislative and other measures taken by it for the purpose of complying with the terms of this Convention.

  1. For the purposes of this Convention, a monitoring group is hereby set up.
  2. Any Party may be represented on the monitoring group by one or more delegates. Each Party shall have one vote.
  3. Any State mentioned in Article 14.1 which is not a Party to this Convention may be represented on the monitoring group by an observer.
  4. The monitoring group may, by unanimous decision, invite any non-member State of the Council of Europe which is not a Party to the Convention and any sports or other professional organisation concerned to be represented by an observer at one or more of its meetings.
  5. The monitoring group shall be convened by the Secretary General. Its first meeting shall be held as soon as reasonably practicable, and in any case within one year after the date of the entry into force of the Convention. It shall subsequently meet whenever necessary, on the initiative of the Secretary General or a Party.
  6. A majority of the Parties shall constitute a quorum for holding a meeting of the monitoring group.
  7. The monitoring group shall meet in private.
  8. Subject to the provisions of this Convention, the monitoring group shall draw up and adopt by consensus its own Rules of Procedure.
  1. The monitoring group shall monitor the application of this Convention. It may in particular:
    1. keep under review the provisions of this Convention and examine any modifications necessary;
    2. approve the list, and any revision thereto, of pharmacological classes of doping agents and doping methods banned by the relevant international sports organisations, referred to in Articles 2.1 and 2.2, and the criteria for accreditation of laboratories, and any revision thereto, adopted by the said organisations, referred to in Article 5.1.a, and fix the date for the relevant decisions to enter into force;
    3. hold consultations with relevant sports organisations;
    4. make recommendations to the Parties concerning measures to be taken for the purposes of this Convention;
    5. recommend the appropriate measures to keep relevant international organisations and the public informed about the activities undertaken within the framework of this Convention;
    6. make recommendations to the Committee of Ministers concerning non-member States of the Council of Europe to be invited to accede to this Convention;
    7. make any proposal for improving the effectiveness of this Convention.
  2. In order to discharge its functions, the monitoring group may, on its own initiative, arrange for meetings of groups of experts.

    After each meeting, the monitoring group shall forward to the Committee of Ministers of the Council of Europe a report on its work and on the functioning of the Convention.

  1. Amendments to the articles of this Convention may be proposed by a Party, the Committee of Ministers of the Council of Europe or the monitoring group.
  2. Any proposal for amendment shall be communicated by the Secretary General of the Council of Europe to the States mentioned in Article 14 and to every State which has acceded to or has been invited to accede to this Convention in accordance with the provisions of Article 16.
  3. Any amendment proposed by a Party or the Committee of Ministers shall be communicated to the monitoring group at least two months before the meeting at which it is to be considered. The monitoring group shall submit to the Committee of Ministers its opinion on the proposed amendment, where appropriate after consultation with the relevant sports organisations.
  4. The Committee of Ministers shall consider the proposed amendment and any opinion submitted by the monitoring group and may adopt the amendment.
  5. The text of any amendment adopted by the Committee of Ministers in accordance with paragraph 4 of this article shall be forwarded to the Parties for acceptance.
  6. Any amendment adopted in accordance with paragraph 4 of this article shall come into force on the first day of the month following the expiration of a period of one month after all Parties have informed the Secretary General of their acceptance thereof.

Final clauses

  1. This Convention shall be open for signature by member States of the Council of Europe, other States party to the European Cultural Convention and non-member States which have participated in the elaboration of this Convention, which may express their consent to be bound by:
    1. signature without reservation as to ratification, acceptance or approval, or
    2. signature subject to ratification, acceptance or approval, followed by ratification, acceptance or approval.
  2. Instruments of ratification, acceptance or approval shall be desposited with the Secretary General of the Council of Europe.
  1. The Convention shall enter into force on the first day of the month following the expiration of a period of one month after the date on which five States, including at least four member States of the Council of Europe, have expressed their consent to be bound by the Convention in accordance with the provisions of Article 14.
  2. In respect of any signatory State which subsequently expresses its consent to be bound by it, the Convention shall enter into force on the first day of the month following the expiration of a period of one month after the date of signature or of the deposit of the instrument of ratification, acceptance or approval.
  1. After the entry into force of this Convention, the Committee of Ministers of the Council of Europe, after consulting the Parties, may invite to accede to the Convention any non-member State by a decision taken by the majority provided for in Article 20.d of the Statute of the Council of Europe and by the unanimous vote of the representatives of the Contracting States entitled to sit on the Committee.
  2. In respect of any acceding State, the Convention shall enter into force on the first day of the month following the expiration of a period of one month after the date of the deposit of the instrument of accession with the Secretary General of the Council of Europe.
  1. Any State may, at the time of signature or when depositing its instrument of ratification, acceptance, approval or accession, specify the territory or territories to which this Convention shall apply.
  2. Any State may, at any later date, by a declaration addressed to the Secretary General, extend the application of this Convention to any other territory specified in the declaration. In respect of such territory the Convention shall enter into force on the first day of the month following the expiration of a period of one month after the date of receipt of such declaration by the Secretary General.
  3. Any declaration made under the two preceding paragraphs may, in respect of any territory mentioned in such declaration, be withdrawn by a notification addressed to the Secretary General. Such withdrawal shall become effective on the first day of the month following the expiration of a period of six months after the date of receipt of the notification by the Secretary General.
  1. Any Party may, at any time, denounce this Convention by means of a notification addressed to the Secretary General of the Council of Europe.
  2. Such denunciation shall become effective on the first day of the month following the expiration of a period of six months after the date of receipt of the notification by the Secretary General.

    The Secretary General of the Council of Europe shall notify the Parties, the other member States of the Council of Europe, the other States party to the European Cultural Convention, the non-member States which have participated in the elaboration of this Convention and any State which has acceded or has been invited to accede to it of:

    1. any signature in accordance with Article 14;
    2. the deposit of any instrument of ratification, acceptance, approval or accession in accordance with Article 14 or 16;
    3. any date of entry into force of this Convention in accordance with Articles 15 and 16;
    4. any information forwarded under the provisions of Article 9;
    5. any report prepared in pursuance of the provisions of Article 12;
    6. any proposal for amendment or any amendment adopted in accordance with Article 13 and the date on which the amendment comes into force;
    7. any declaration made under the provisions of Article 17;
    8. any notification made under the provisions of Article 18 and the date on which the denunciation takes effect;
    9. any other act, notification or communication relating to this Convention.

    In witness whereof the undersigned, being duly authorised thereto, have signed this Convention.
    Done at Strasbourg, the 16th day of November 1989, in English and French, both texts being equally authentic, in a single copy which shall be deposited in the archives of the Council of Europe. The Secretary General of the Council of Europe shall transmit certified copies to each member State of the Council of Europe, to the other States party to the European Cultural Convention, to the non-member States which have participated in the elaboration of this Convention and to any State invited to accede to it.

Appendix – List of prohibited pharmacological classes of doping agents and doping methods
(Status as of 31 March 2000. The appendix is regularly revised by the Monitoring Group on the basis of the anti-doping list of the International Olympic Committee.)

    I. PROHIBITED CLASSES OF SUBSTANCES

    A. Stimulants
    B. Narcotics
    C. Anabolic Agents
    D. Diuretics
    E. Peptide hormones, mimetics and analogues

    II. PROHIBITED METHODS

    III. CLASSES OF PROHIBITED SUBSTANCES IN CERTAIN CONDITIONS

    A. Alcohol
    B. Cannabinoids
    C. Local anaesthetics
    D. Glucocorticosteroids
    E. Beta-blockers

    IV. OUT-OF-COMPETITION TESTING

    Appendix to the Reference List

  

I. PROHIBITED CLASSES OF SUBSTANCES

A. Stimulants

Prohibited substances in class (A) include the following examples :

amineptine, amiphenazole, amphetamines, bromantan, caffeine*, carphedon, cocaine, ephedrines**, fencamfamin, mesocarb, pentetrazol, pipradol, salbutamol***, salmeterol***, terbutaline***, … and related substances.

* For caffeine the definition of a positive is a concentration in urine greater than 12 micrograms per millilitre.

** For cathine, the definition of a positive is a concentration in urine greater than 5 micrograms per millilitre. For ephedrine, and methylephedrine, the definition of a positive is a concentration in urine greater than 10 micrograms per millilitre. For phenylpropanolamine and pseudoephedrine the definition of a positive is a concentration in urine greater than 25 micrograms per millilitre.

*** Permitted by inhaler only to prevent and/or treat asthma and exercise-induced asthma. Written notification of asthma and/or exercise-induced asthma by a respiratory or team physician is necessary to the relevant medical authority.

NOTE: All imidazole preparations are acceptable for topical use. Vasoconstrictors may be administered with local anaesthetic agents. Topical preparations (e.g. nasal, ophtalmological, rectal) of adrenaline and phenylephrine are permitted.

B. Narcotics

Prohibited substances in class (B) include the following examples:

buprenorphine, dextromoramide, diamorphine (heroin), methadone, morphine, pentazocine, pethidine, … and related substances.

NOTE: codeine, dextromethorphan, dextropropoxyphene, dihydrocodeine, diphenoxylate, ethylmorphine, pholcodine, propoxyphene and tramadol are permitted.

C. Anabolic agents

Prohibited substances in class (C) include the following examples:

1. Anabolic androgenic steroids

a.    clostebol, fluoxymesterone, metandienone, metenolone, nandrolone, 19-norandrostenediol, 19-norandrostenedione, oxandrolone, stanozolol, … and related substances.

b.    androstenediol, androstenedione, dehydroepiandrosterone (DHEA), dihydrotestosterone, testosterone*, … and related substances.

Evidence obtained from metabolic profiles and/or isotopic ratio measurements may be used to draw definitive conclusions.

* The presence of a testosterone (T) to epitestosterone (E) ratio greater than six (6) to one (1) in the urine of a competitor constitutes an offence unless there is evidence that this ratio is due to a physiological or pathological condition, e.g. low epitestosterone excretion, androgen producing tumour, enzyme deficiencies.

In the case of T/E higher than 6, it is mandatory that the relevant medical authority conduct an investigation before the sample is declared positive. A full report will be written and will include a review of previous tests, subsequent tests and any results of endocrine investigations. In the event that previous tests are not available, the athlete should be tested unannounced at least once per month for three months. The results of these investigations should be included in the report. Failure to cooperate in the investigations will result in declaring the sample positive.

2. Beta-2 agonists

bambuterol, clenbuterol, fenoterol, formoterol, reproterol, salbutamol*, terbutaline*, … and related substances.

* Permitted by inhalation as described in Article (I.A).

D. Diuretics

Prohibited substances in class (D) include the following examples:

acetazolamide, bumetanide, chlorthalidone, ethacrynic acid, furosemide, hydrochlorothiazide, mannitol*, mersalyl, spironolactone, triamterene, … and related substances.

* Prohibited by intravenous injection.

E. Peptide hormones, mimetics and analogues

Prohibited substances in class (E) include the following examples and their analogues and mimetics:

1. Chorionic Gonadotrophin (hCG) prohibited in males only;
2. Pituitary and synthetic gonadotrophins (LH) prohibited in males only;
3. Corticotrophins (ACTH, tetracosactide);
4. Growth hormone (hGH);
5. Insulin-like Growth Factor (IGF-1);

and all the respective releasing factors and their analogues;

6. Erythropoietin (EPO);
7. Insulin;

permitted only to treat certified insulin-dependent diabetes. Written notification of insulin-dependent diabetes must be obtained from an endocrynologist or team physician.

The presence of an abnormal concentration of an endogenous hormone in class (E) or its diagnostic marker(s) in the urine of a competitor constitutes an offence unless it has been proven to be due to a physiological or pathological condition.

II. PROHIBITED METHODS

The following procedures are prohibited:

1.    Blood doping;
2.    Administering artificial oxygen carriers or plasma expanders;
3.    Pharmacological, chemical and physical manipulations.

III. CLASSES OF PROHIBITED SUBSTANCES IN CERTAIN CIRCUMSTANCES

A. Alcohol

Where the rules of a responsible authority so provide, tests will be conducted for ethanol.

B. Cannabinoids

Where the rules of a responsible authority so provide, tests will be conducted for cannabinoids (e.g. Marijuana, Hashish). At the Olympic Games, tests will be conducted for cannabinoids. A concentration in urine of 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (carboxy-THC) greater than 15 nanograms per millilitre constitutes doping.

C. Local anaesthetics

Injectable local anaesthetics are permitted under the following conditions:

a.    bupivacaine, lidocaine, mepivacaine, procaine, and related substances, can be used but not cocaine. Vasoconstrictor agents may be used in conjunction with local anaesthetics;
b.    only local or intra-articular injections may be administered;
c.    only when medically justified.

Where the rules of a responsible authority so provide, notification of administration may be necessary.

D. Glucocorticosteroids

The systemic use of glucocorticosteroids is prohibited when administered orally, rectally, or by intravenous or intramuscular injection.

E. Beta-blockers

Prohibited substances in class (E) include the following examples :

acebutolol, alprenolol, atenolol, labetalol, metoprolol, nadolol, oxprenolol, propranolol, sotalol, … and related substances.

Where the rules of a responsible authority so provide, tests will be conducted for beta-blockers.

  

SUMMARY OF URINARY CONCENTRATIONS
ABOVE WHICH I.O.C. ACCREDITED LABORATORIES
MUST REPORT FINDINGS FOR SPECIFIC SUBSTANCES

caffeine > 12 micrograms / millilitre
carboxy-THC > 15 nanograms / millilitre
cathine > 5 micrograms / millilitre
ephedrine > 10 micrograms / millilitre
epitestosterone > 200 nanograms / millilitre
methylephedrine > 10 micrograms / millilitre
morphine > 1 microgram / millilitre
19-norandrosterone > 2 nanograms / millilitre in males
19-norandrosterone > 5 nanograms / millilitre in females
phenylpropanolamine > 25 micrograms / millilitre
pseudoephedrine > 25 micrograms / millilitre
salbutamol
(out-o-competition testing)		 > 1000 nanograms / millilitre
T/E ratio > 6

IV. OUT-OF-COMPETITION TESTING

Unless specifically requested by the responsible authority, out-of-competition testing is directed solely at prohibited substances in class I.C (Anabolic Agents), I.D. (Diuretics), I.E. (Peptide Hormones, Mimetics and Analogues), and II (Prohibited Methods).

  

LIST OF EXAMPLES OF PROHIBITED SUBSTANCES

CAUTION: This is not an exhaustive list of prohibited substances. Many substances that do not appear on this list are considered prohibited under the term "and related substances".

Athletes must ensure that any medicines, supplement, over-the-counter preparation or any other substances they use does not contain any prohibited substance.

STIMULANTS:

amineptine, amfepramone, amiphenazole, amphetamine, bambuterol, bromantan, caffeine, carphedon, cathine, cocaine, cropropamide, crotethamide, ephedrine, etamivan, etilamphetamine, etilefrine, fencamfamin, fenetylline, fenfluramine, formoterol, heptaminol, mefenorex, mephentermine, mesocarb, methamphetamine, methoxyphenamine, methylendioxyamphetamine, methylephedrine, methylphenidate, nikethamide, norfenfluramine, parahydroxyamphetamine, pemoline, pentetrazol, phendimetrazine, phentermine, phenylephrine, phenylpropanolamine, pholedrine, pipradrol, prolintane, propylhexedrine, pseudoephedrine, reproterol, salbutamol, salmeterol, selegiline, strychnine, terbutaline,

NARCOTICS:

buprenorphine, dextromoramide, diamorphine (heroin), hydrocodone, methadone, morphine, pentazocine, pethidine,

ANABOLIC AGENTS:

androstenediol, androstenedione, bambuterol, boldenone, clenbuterol, clostebol, danazol, dehydrochlormethyltestosterone, dehydroepiandrosterone (DHEA), dihydrotestosterone, drostanolone, fenoterol, fluoxymesterone, formebolone, formoterol, gestrinone, mesterolone, metandienone, metenolone, methandriol, methyltestosterone, mibolerone, nandrolone, 19-norandrostenediol, 19-norandrostenedione, norethandrolone, oxandrolone, oxymesterone, oxymetholone, reproterol, salbutamol, salmeterol, stanozolol, terbutaline, testosterone, trenbolone,

DIURETICS:

acetazolamide, bendroflumethiazide, bumetanide, canrenone, chlortalidone, ethacrynic acid, furosemide, hydrochlorothiazide, indapamide, mannitol, mersalyl, spironolactone, triamterene,

MASKING AGENTS:

bromantan, diuretics (see above), epitestosterone, probenecid,

PEPTIDE HORMONES, MIMETICS AND ANALOGUES:

ACTH, erythropoietin (EPO), hCG*, hGH, insulin, LH*, clomiphene*, cyclofenil*, tamoxifen*,
* Prohibited in males only.

BETA BLOCKERS:

acebutolol, alprenolol, atenolol, betaxolol, bisoprolol, bunolol, carteolol, celiprolol, esmolol, labetalol, levobunolol, metipranolol, metoprolol, nadodol, oxprenolol, pindolol, propranolol, sotalol, timolol.

  

APPENDIX

Salbutamol

Salbutamol is classified as both a stimulant and an anabolic agent.

The intent of out-of-competition testing is to detect anabolic agents. The revised rules on salbutamol consider it as anabolic agent when its concentration is higher than 500 manograms/millilitre and confirmed by enantiomeric analysis.

However, pending the acceptance of the enantiomeric analysis by a peer-reviewed journal, only concentrations higher than 1000 manograms/millilitre will be considered positive as an anabolic agent until further notice. Samples that contain less than this amount are not to be reported to the authorities for out-of-competition testing.

In-competition testing is designed to detect the use of salbutamol either as an anabolic agent or as a stimulant. Whether or not the administration of salbutamol is declared is an important issue for in-competition testing.

As always, it is the task of the authorities to interpret the laboratory finding. In order not to overload authorities with the need to confirm medical notifications of non-recent inhaled use, laboratories do not need to report concentrations lower than 100 manograms/millilitre.

All concentrations above correspond to free (non conjugated) salbutamol.

Ephedrines

The pharmacology and urinary pharmacokinetics of the ephedrines were reviewed. The consensus was that the revised cut-offs would detect all cases of doping where the ephedrines were ingested on the day of competition.

 

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